Weve Got Issues: Children and Parents in the Age of Medication.

‘Ask the Doctor Session’ on Children and Adolescents (3:15 p.m.D.. 2010 NAMI National Convention to address concerns for child and adolescent mental health The National Alliance on Mental Illness will address concerns for child and adolescent mental health at the 2010 NAMI National Convention in Washington, D.C., July 1-3. The 2010 NAMI Convention also will honor journalist Judith Warner with an award for the written book, We’ve Got Issues: Children and Parents in the Age of Medication, which explores hard decisions parents face to find help for kids who ‘suffer enormously’ from mental illness. Only 1 in five children who has a diagnosable mental illness receives treatment, yet kids who receive previous treatment interventions possess better outcomes.The presence of multiple subclones, inferred from significantly different variant allele frequencies of distinct mutations in targeted sequencing at 6 months after treatment, was confirmed through whole-exome sequencing that uncovered additional new mutations. A more detailed evaluation of clonal evolution was obtained simply by the sequencing of serial samples from 35 individuals that spanned years. Generally in most patients, clonal hematopoiesis comes from a clone that was present during diagnosis already. However, the next temporal course of these clones was highly variable. In some full cases, clones containing mutations had been stable over a period of years , generally with persistent cytopenias . In others , a large hematopoietic stem-cell clone dominated the blood compartment, and new subclones were observed preceding the development of myelodysplastic syndromes, AML, or both .