ARIAD initiates multi-middle ponatinib Phase 1/2 clinical trial for CML in Japan ARIAD Pharmaceuticals, Inc. today announced the initiation of a multi-center Phase 1/2 medical trial in Japan of ponatinib, the Company’s investigational BCR-ABL inhibitor. The trial has been conducted in Japanese patients with chronic myeloid leukemia who’ve failed treatment with dasatinib or nilotinib or with Philadelphia-chromosome positive acute lymphoblastic leukemia who have failed prior tyrosine kinase inhibitors.1) Bloodstream IN THE STOOLS OR RECTAL BLEEDING: – This is probably the number one symptom of cancer of the colon. With this kind of tumor the tumour develops in the ultimate section of the digestive tract. Therefore, if the tumour bleeds a few of this blood comes from the rectum or in your stool usually. The bleeding is not usually significant but if you see any at all then you should inform your physician immediately. 2) PAIN IN THE STOMACH: – If the tumour gets large enough it can result in a blockage in your colon. This blockage can prevent solids, liquids or gases passing through your bowel that leads to cramps and pains in that case. In the worst instances, the tumour can grow so huge that it breaks through your bowel wall which again causes major stomach pains.