Santhosh Girirajan.

Santhosh Girirajan, M.B., B levitra online .S., Ph.D., A Jill. Rosenfeld, M.S., Bradley P. Coe, Ph.D., Sumit Parikh, M.D., Neil Friedman, M.B., Ch.B., Amy Goldstein, M.D., Robyn A. Filipink, M.D., Juliann S. McConnell, M.S., Brad Position, M.D., Wendy S. Meschino, M.D., Marjan M. Nezarati, M.D., Alexander Asamoah, M.D., Kelly E. Jackson, M.S., Gordon C. Gowans, M.D., Judith A. Martin, M.D., Erin P. Carmany, M.S., David W. Stockton, M.D., Rhonda E. Schnur, M.D., Lynette S. Penney, M.D., Donna M. Martin, M.D., Ph.D., Salmo Raskin, Ph.D., Kathleen Leppig, M.D., Heidi Thiese, M.S., Rosemarie Smith, M.D., Erika Aberg, M.S., Dmitriy M. Niyazov, M.D., Luis F. Escobar, M.D., Dima El-Khechen, M.S., Kisha D.

Kang, Sc.D., Majken K. Jensen, Ph.D., Gary C. Curhan, Sc.D., Louis R. Pasquale, M.D., Paul M. Ridker, M.D., M.P.H., David J. Hunter, M.B., B.S., Sc.D., Walter C. Willett, M.D., Dr.P.H., Eric B. Rimm, Sc.D., Daniel I. Chasman, Ph.D., Frank B. Hu, M.D., Ph.D., and Lu Qi, M.D., Ph.D.: Sugar-Sweetened Beverages and Genetic Threat of Obesity Obesity has turned into a major danger to public health through the entire global world.1 The dramatic changes in diet and lifestyle during the past three years are thought to have played a key part in triggering the obesity epidemic.2 Previously several years, large-scale genomewide association studies have successfully identified multiple loci linked to the body-mass index ; these loci contain distributed variants that determine the entire susceptibility to weight problems commonly.3 A meta-analysis of genomewide association studies has generated that 32 loci are associated with BMI at a genomewide significance level.4,5 However, few studies possess examined the interaction between environmental factors and the genetic predisposition to adiposity.2 In the past 30 years, the intake of sugar-sweetened beverages dramatically has increased.6 Compelling evidence helps a positive hyperlink between the consumption of sugar-sweetened drinks and the risk of obesity.6-11 The temporal patterns in the increasing intake of these beverages have got paralleled the rise in the prevalence of obesity6; in the United States, both the intake of sugar-sweetened drinks and the prevalence of obesity have significantly more than doubled since the late 1970s.12 Therefore, we hypothesized a high intake of sugar-sweetened beverages would impact the association between the genetic predisposition and adiposity.