Promoting patient safety Aetna also offers established new plans regarding Serious Reportable Occasions . A list of 28 significant reportable events was initially set up by the Leapfrog Group, and endorsed and additional refined by the National Quality Discussion board , a not-for-profit firm intended to develop and implement a national technique for healthcare quality reporting and measurement. Additionally, facilities, doctors and other healthcare professionals will be asked to waive all charges related to the three Under no circumstances Events.Among the 23 individuals, 1 had metastatic disease, 18 got undergone previous surgery, and 4 experienced received prior treatment with imatinib or nilotinib. All 23 patients enrolled in the extension study were contained in the safety analysis. The median duration of treatment for these individuals was 244 days , and the mean was 254 days . A complete of 14 patients had a dose reduction, and 7 experienced a temporary medication withdrawal. The most typical reason for dose alteration was fatigue. Treatment-related adverse events that occurred in 25 percent or more of the study population included adjustments in hair color , fatigue , nausea , dysgeusia , and periorbital edema .