Enrico Tiacci, M.D http://suhagrastore.com/reviews ., Vladimir Trifonov, Ph.D., Gianluca Schiavoni, Ph.D., Antony Holmes, Ph.D., Wolfgang Kern, M.D., Maria Paola Martelli, M.D., Alessandra Pucciarini, Ph.D., Barbara Bigerna, B.Sc., Roberta Pacini, B.Sc., Victoria A. Wells, B.Sc., Paolo Sportoletti, M.D., Valentina Pettirossi, Ph.D., Roberta Mannucci, Ph.D., Oliver Elliott, M.Sc., Arcangelo Liso, M.D., Achille Ambrosetti, M.D., Alessandro Pulsoni, M.D., Francesco Forconi, M.D., Livio Trentin, M.D., Gianpietro Semenzato, M.D., Giorgio Inghirami, M.D., Monia Capponi, M.D., Francesco Di Raimondo, M.D., Caterina Patti, M.D., Luca Arcaini, M.D., Pellegrino Musto, M.D., Stefano Pileri, M.D., Claudia Haferlach, M.D., Susanne Schnittger, Ph.D., Giovanni Pizzolo, M.D.D., Laurent Farinelli, Ph.D., Torsten Haferlach, M.D., Laura Pasqualucci, M.D., Raul Rabadan, Ph.D., and Brunangelo Falini, M.D.: BRAF Mutations in Hairy-Cell Leukemia Hairy-cellular leukemia is a definite disease entity that is seen as a an indolent training course, marked splenomegaly, progressive pancytopenia in many cases, and rare circulating tumor cells, usually with no lymphadenopathy.1 The bone marrow, spleen, and liver are characteristically infiltrated by leukemic B cells which have abundant cytoplasm with hairy-looking projections and unique immunophenotypic features.2,3 Currently, the treatment of HCL is based on highly effective purine nucleoside analogues.4 In spite of the exceptional progress in the diagnosis and treatment of HCL in the past 50 years, the underlying genetic alterations that cause the condition remain obscure.3 Main obstacles to molecular characterization of HCL have been the scarcity of tumor cells available for analysis , the low proliferative index of leukemic cells and the inability to develop them in immunodeficient mice, and the lack of individual cell lines of authentic HCL origin.
Marcelo Cypel, M.D., Jonathan C. Yeung, M.D., Mingyao Liu, M.D., Masaki Anraku, M.D., Fengshi Chen, M.D., Ph.D., Wojtek Karolak, M.D., Masaaki Sato, M.D., Ph.D., Jane Laratta, R.N., Sassan Azad, C.R.A., Mindy Madonik, C.C.P., Chung-Wai Chow, M.D., Cecilia Chaparro, M.D., Michael Hutcheon, M.D., Lianne G. Singer, M.D., Arthur S. Slutsky, M.D., Kazuhiro Yasufuku, M.D., Ph.D., Marc de Perrot, M.D., Andrew F. Pierre, M.D., Thomas K. Waddell, M.D., Ph.D., and Shaf Keshavjee, M.D.: Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation.