Abuse of painkillers may predispose adolescents to lifelong addiction No young child aspires to a lifetime of addiction. But their brains might. In new research to seem online in the journal Neuropsychopharmacology today, Rockefeller University experts reveal that adolescent brains subjected to the painkiller OxyContin can sustain lifelong and long term changes within their reward system – adjustments that increase the drug’s euphoric properties and make such adolescents even more vulnerable to the drug’s results later in adulthood Get more information . The extensive analysis, led by Mary Jeanne Kreek, head of the Laboratory of the Biology of Addictive Diseases, may be the first to directly compare levels of the chemical substance dopamine in adolescent and adult mice in response to raising dosages of the painkiller.
Harkness lately presented her findings at the International Culture for Affective Disorders Conference in Toronto.. Abuse during childhood boosts risk of major depression in adolescence substantially Queen’s University professor Kate Harkness has found that a brief history of physical, sexual or emotional misuse in childhood substantially increases the risk of despair in adolescence by altering a person’s neuroendocrine response to stress. Adolescents with a history of maltreatment and a gentle level of major depression were found to release much even more of the stress hormone cortisol than is usually regular in response to psychological stressors such as offering a speech or solving a hard arithmetic test. Harkness, a professor in the Section of Psychology and an expert in the role of tension and trauma in adolescent unhappiness.