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Clinical Assessments Assessments created before enrollment are summarized in Desk 2 in the Supplementary Appendix. Evaluation of the tumor for a reply to treatment was performed by way of computed tomography every 2 a few months. Unidirectional measurements were adopted on the basis of the Response Evaluation Requirements in Solid Tumors .17 Progression-free of charge survival was evaluated for the period from the date of randomization to the date when disease progression was initially observed or death occurred. Treatment response and progression-free survival were dependant on external overview of the CT movies by experts who were not aware of the treatment assignments. General survival was evaluated for the period from the day of randomization to the day of death.